A carpal tunnel relief device is configured for adhesive application to a skin area above the median nerve of the distal forearm, wrist or a palm of the subject and includes a middle curved portion shaped to pull the skin and surrounding soft tissues away from the median nerve therefore releasing compression of the median nerve and pain associated with carpal tunnel syndrome. Resilient flexible member may be incorporated with the device or inserted in a pocket of a flexible fabric after its adhesion to the skin.