Methods of treatment of cancer are disclosed through administration of siRNA and shRNA sequences silencing BORIS gene and isoforms thereof. One embodiment of the invention discloses pharmaceutical compositions and kits for modifying the palliative procedure of transarterial chemoembolization so as to promote uptake of gene silencing inducing agents into the hepatic cancer microenvironment. By selectively administering under localized increased pressure, enhanced uptake of gene silencing agents is achieved, thus increasing targeting of tumor cells, particularly stem cells.
