A method of depositing at least one substance on a target substrate (1) comprises the step of operating at least one droplet dispenser (21) such that droplets (2) including the at least one substance are deposited on the target substrate (1), wherein the target substrate (1) has a substrate surface including spatially delimited receptacle sections (3) being arranged for accommodating the droplets (2), and the at least one droplet dispenser (21) is controlled in dependency on the locations of the receptacle sections (3) such that the droplets (2) are directed onto the receptacle sections (3). Furthermore, a dispenser device (100) for depositing at least one substance on a target substrate (1) is described.