VARNEY, TIMOTHY R,MILLS, CHARLES R,DANILKOVITCH, ALLA
申请号：
NZ58780909
公开号：
NZ587809A
申请日:
2009.03.04
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Discloses the use of isolated exogenous allogeneic mesenchymal stem cells in the manufacture of a medicament for completely re-populating a host tissue with exogenous mesenchymal stem cells. The exogenous allogeneic mesenchymal stem cells must express either or both markers CD75 and CD105. Further discloses that the native endogenous mesenchymal stem cell population of the host tissue is reduced to a point where the host tissue is substantially free of endogenous mesenchymal stem cells. Further discloses that the medicament may be adapted for administration with hematopoietic stem cells that are HLA-matched to the host. Further discloses that the mesenchymal stem cells may contain a selected transgene.
