VANDECRUYS ROGER PETRUS GEREBERN,JANS EUGEEN MARIE JOZEF
申请号：
NO20014724
公开号：
NO332167B1
申请日:
2001.09.28
申请国别(地区):
NO
年份:
2012
代理人:
摘要：
The present invention concerns a hydrophilic controlled release formulation, more in particular a hydrophilic controlled release matrix formulation, and solid dosage forms prepared therefrom, preferably for once daily oral administration. The hydrophilic controlled release formulation comprises pregelatinized starch, one or more active ingredients, one or more viscous hydrophilic polymers and optionally pharmaceutically acceptable formulating agents. Preferred hydrophilic polymers include hydroxypropyl cellulose and hydroxypropyl methylcellulose.Foreliggende oppfinnelse vedrører anvendelse av pre- gelatinisert stivelse for å forhindre dose-dumping fra en hydrofil regulert frigivende formulering. Den vedrører også en hydrofil regulert frigivende formulering, nærmere bestemt en hydrofil regulert frigivende matriksformulering, og faste doseringsformer fremstilt derfra, fortrinnsvis for administrasjon en gang om dagen. Den hydrofile regulert frigivende formulering omfatter pregelatinisert stivelse, en eller flere aktive ingredienser, en eller flere viskøse hydrofile polymerer og eventuelt farmasøytisk akseptable formuleringsmidler. Foretrukne hydrofile polymerer omfatter hydroksypropylcellulose og hydroksypropylmetylcellulose.
