Rall, Werner,Soyka, Rainer,Kulinna, Christian,Schnaubelt, Juergen,Sieger, Peter
申请号：
AU2011201171
公开号：
AU2011201171B2
申请日:
2011.03.16
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011201171B220120209.pdf#####C. NRPorlOCC AMT 3533881 1.DOC-15/03/2011 Method for the production of amino crotonyl compounds ABSTRACT The invention relates to an improved method for the production of 4-[(3-chloro-4fluorophenyl)amino]-6-([4-(N,N-dimethylamino)-1 -oxo-2-butene-1 -yl]amino}-7-((S)tetrahydrofurane-3-yloxy)-quinazoline and related amino crotonyl compounds. The invention also relates to a suitable salt of 4-[(3-chloro-4-fluorphenyl)amino]-6-{[4(N,N-dimethylamino)-1-oxo-2-butene-1 -yl]amino}-7-((S)-tetrahydrofurane-3-yloxy)quinazoline for use as an active ingredient for a medicament.
