BUENO MELENDO, ANA BELEN,FRANCISKOVICH, JEFFRY BERNARD,LIU, BIN,TAKEUCHI, KUMIKO,BARRETT, DAVID GENE
申请号：
PE0000412012
公开号：
PE10452012A1
申请日:
2010.07.12
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a Formila Compound I, where X is n, CH ra IS F, CF3, RB and RC are each F, Methyl or combine to form cycloalkyl c3-c5 r1 is H, Methyl R2 is H, F.Preferred compounds are: 5 - [1 - (2 - fluoro - 2 - Methyl Propyl) piperidin-4-yl] - 1 - metansulfonil ilmetoxi - 1, 2 , 3, 6 - tetrahydro - [] bipiridinilo 2,4 - metansulfonil 1 - [1 - (4 - 4 - (trifluoromethyl ciclopropilmetil 1 - - - ilmetoxi) piperidin-4-yl] - phenyl} - 1,2,3,6 - tetrahydro - pyridine. These compounds are useful in the treatment of Type II diabetesREFERIDA A UN COMPUESTO DE FORMILA I, DONDE X ES N, CH Ra ES F, CF3 Rb Y Rc SON CADA UNO F, METILO O SE COMBINAN PARA FORMAR CICLOALQUILO C3-C5 R1 ES H, METILO R2 ES H, F. SON COMPUESTOS PREFERIDOS: 5-[1-(2-FLUORO-2-METIL-PROPIL)-PIPERIDIN-4-ILMETOXI]-1-METANSULFONIL-1,2,3,6-TETRAHIDRO-[2,4]BIPIRIDINILO 1-METANSULFONIL-4-{4-[1-(1-TRIFLUOROMETIL-CICLOPROPILMETIL)-PIPERIDIN-4-ILMETOXI]-FENIL}-1,2,3,6-TETRAHIDRO-PIRIDINA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE DIABETES TIPO II
