Compositions and related methods of treating diseases of the pilosebaceous unit including acne, rosacea and hidradenitis. Through the introduction of active ingredients including xylitol and farnesol at a treatment location, biofilms associated with acne, roasacea and hidradenitis are disrupted and/or inhibited. The composition can be in the form of a topical medication or cream including a pharmaceutically acceptable carrier and the active ingredients. The composition can further comprise beneficial skin supplements to further enhance the treatment effects. The composition can be utilized in conjunction with additional biofilm disruption treatments.
