A combination of a vascular hole closure device and a delivery instrument for delivering the vascular hole closure device. The combination comprises a vascular hole closure device (104) and a delivery instrument (10). The vascular hole closure device (100) has a covering member (104) at a distal end for positioning internal of a vessel, a first retainer (110) for positioning external of the vessel, a first flexible member (122) extending between the covering member and first retainer, and a first engagement member (131) at a proximal portion (122a) of the flexible member. The delivery instrument (10) includes a housing (12) having a first stop (32), the first engagement member being engageable with the first stop and overriding the first stop when a predetermined proximal force is applied to the delivery instrument, wherein proximal movement of the delivery instrument advances the first retainer toward the covering member.
