A toothbrush and toothpaste combination assembly includes a housing that has a top wall, a bottom wall and a perimeter wall attached to and extending therebetween. A toothpaste is contained within the housing. A brush is coupled to the housing. A toothpick is coupled to the bottom wall of the housing. An actuating apparatus is provided. The actuating apparatus is in mechanical communication with the toothpaste. The actuating apparatus is actuated to urge the toothpaste through the brush. A top cap is removably coupled to the top wall to cover the brush. A bottom cap is removably coupled to the bottom wall to cover the toothpick.