Laquinimod for use in the treatment of Huntington's disease. A method of increasing brain-derived neurotrophic factor (BDNF) serum level in a human subject comprising periodically administering to the subject an amount of laquinimod or pharmaceutically acceptable salt thereof. The method can further comprise periodically administering to the subject an amount of a second BDNF-increasing agent. A method for treating a human subject suffering from a BDNF-related disease comprising periodically administering laquinimod or a pharmaceutically acceptable salt thereof in an amount effective to treat the human subject. Use of laquinimod in the manufacture of a medicament for increasing BDNF serum level in a human subject. A pharmaceutical preparation comprising an amount of laquinimod and an amount of a second BDNF-increasing agent effective for use in increasing BDNF serum level in a human subject.
