Marcelo Mantovani Martiniano de Azevedo,Nélson Eduardo Durán Caballero
申请号：
BRPI0404306
公开号：
BRPI0404306B1
申请日:
2004.09.28
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
"polymeric nanoparticle incorporating a compound having pharmaceutical or cosmetic properties, its process for obtaining and cosmetic or pharmaceutical composition containing the polymeric nanoparticles." The present invention relates to smaller and less aggregated polymeric nanoparticles, compositions containing these polymeric nanoparticles and the process of preparing these polymeric nanoparticles using two surfactants, also polymeric, to incorporate drugs or cosmetics, preferably the same. hydrophobic drugs, in order to increase their stability, their therapeutic or cosmetic efficacy on specific targets and provide a slow and continuous release of the encapsulated drug or cosmetic. More specifically, the process of the present invention describes the preparation of biodegradable polymer nanospheres, such as poly (lactide co-glycolide), by the modified solvent-diffusion-evaporated nanoprecipitation method using two surfactants at the same time. such as pluronic f-68 ^ <；32>； ^ poly (ethylene oxide) poly (propylene oxide) poly (ethylene oxide), 8400 molar mass, or other block copolymers, and pva poly (vinyl alcohol), of 127,000 molar mass, thus providing savings in the amount of the drug or encapsulated cosmetic as well as the adjuvants used in the final formulation of the product."nanopartícula polimérica incorporando um composto com propriedades farmacêuticas ou cosméticas, seu processo de obtenção e composição cosmética ou farmacêutica contendo as nanoparticulas poliméricas". a presente invenção está relacionada com nanopartículas poliméricas de menor tamanho e menos agregadas, composições contendo estas nanopartículas poliméricas e com o processo de preparação destas nanopartículas poliméricas utilizando-se, para isso, dois surfactantes, também poliméricos, para incorporar fármacos ou cosméticos, preferencialmente os fármacos hidrofóbicos, com o intuito de aumentar sua estabilidade, sua eficácia terapêutica ou cosmética em alvos específicos e proporcionar
