This invention presented is a composition and method for prevention and treatment of Alzheimer’s disease, the composition comprising monacolins and anti-inflammation agents is made by the method of the invention. The composition of the invention has effect on prevention and treatment of Alzheimer’s disease without noticeable side effects caused to patients.本發明揭露一種治療與預防阿茲海默症之組合物及其製作方法,其係為一包含莫那可林(monacolins)與抗發炎物質之組合物。利用此二類物質所形成之組合物來治療與預防阿茲海默症並透過本發明之製作方法加以實施,可達到確實治療與預防以及不會產生明顯副作用之功效者。