The present invention relates to a portable medical platform system of an endoscope, which includes a camera head, a tube, a handle, and a portable main system. The camera head having light sources, a sensor, and an image signal processor is mounted in a distal end of the tube. The other proximal end of the tube is connected with the handle which has provided with several functional buttons thereon for electrically connecting with a control board to control actions of light sources and the camera head wherein the portable main system is also connected with the control board. By providing the control system on the handle with separated control board, the invention therefore obtains utility and improvement for a medical surgery.