Saccharide conjugate vaccines comprising CD4+ T cell epitopes selected from tetanus toxin, Plasmodium falciparum circumsporozoite protein (PfCSP), Hepatitis B virus nucleocapsid (HBVnc), Influenza virus haemagglutinin (HA), Hepatitis B virus surface antigen (HBsAg) and Influenza virus matrix protein (MT) and a saccharide antigen
593954 Disclosed is a composition comprising a combination of two or more monovalent conjugates, wherein each of said two or more monovalent conjugates comprises a carrier protein comprising CD4 T cell epitopes from two or more pathogen conjugated to a saccharide antigen, wherein: The epitopes are selected from tetanus toxin (TT), Plasmodium falciparum circumsporozoite protein (PfCSP), Hepatitis B virus nucleocapsid (HBVnc), Influenza virus haemagglutinin (HA), Hepatitis B virus surface antigen (HBsAg) and Influenza virus matrix protein (MT) and At least one of the conjugates comprises a saccharide antigen other than Haemophilus influenza type b (Hib).
