A person positioning and health care monitoring system includes a monitoring center, a RFID tag device, and a tracking module. The monitoring center includes positioning data corresponding to a target. The RFID tag device is located on the target and includes a memory storing a target identification (ID) number and an infrared LED. Each tracking module includes infrared cameras and an RFID device. The tracking module uses the RFID device to communicate with the RFID tag device so as to receive the target identification (ID) number. The tracking module communicates with the monitoring center so as to provide the target identification (ID) number and orientation data corresponding to the target for the monitoring center. The monitoring center determines coordinates of the target according to coordinates of the tracking module and the orientation data corresponding to the target.