David-Huy Nhu Nguyen,Daniel Griffith Anderson,Robert S. Langer,Kerry Peter Mahon
申请号：
US13126260
公开号：
US20120009222A1
申请日:
2009.10.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynucleotide, which are then administerd to a subject. Such compositions have been found to stimulate the production of cytokines and increase both humoral and cell-mediate immune response. The invention also provides pharmaceuti-cal compositions thereof and methods for using the same.
