The present invention relates to dual delta (δ) and gamma (γ) PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of Pi3K kinase mediated diseases or disorders with them.本發明係關於雙重德爾塔(δ)及伽馬(γ)PI3K蛋白激酶調節劑、其製備方法、含有其之醫藥組合物及用其治療、預防及/或改善Pi3K激酶介導之疾病或病症的方法。