Andrew J. Boydston,Neal A. Yakelis,Ronald Jay Berenson,Derek C. Church,Gregory I. Peterson,Michael Larsen
申请号：
US14650221
公开号：
US20150368403A1
申请日:
2013.12.09
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.
