Substituted heterocycles of general structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: R<1> is selected from the group consisting of: hydrogen C1-6 alkyl, unsubstituted or substituted C2-6 alkenyl, unsubstituted or substituted C2-6 alkynyl phenyl, unsubstitued or substituted X is selected from the group consisting of: -O-, -S-, -SO-, -SO2- Y is selected from the group consisting of: a single bond, -O-, -S-, -CO-, -CH2, -CHR5- and -CR<15>R<16> Z = C1-6 alkyl, are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
