EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION;이화여자대학교 산학협력단
发明人:
RYU, Kyung Ha,유경하,WOO, So Youn,우소연,KIM, Han Su,김한수,PARK, Joo Won,박주원,KIM, Yu Hee,김유희,CHO, Kyung Ah,조경아,PARK, Min Hwa,박민화
申请号：
KRKR2019/014042
公开号：
WO2020/101212A1
申请日:
2019.10.24
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a composition for inhibiting cancer metastasis, or preventing, alleviating, or treating cancer, comprising a conditioned medium of tonsil-derived mesenchymal stem cells. Having a protein profile different from those of mesenchymal stem cells derived from other tissues or conditioned media thereof, the composition of the present invention exhibits inhibitory activity against EMT to suppress cancer metastasis, such as cancer cell motility and penetration, at the early stage and to induce the apoptosis of cancer cells. Thus, the composition has excellent effects of inhibiting cancer metastasis and preventing, alleviating, and treating cancer.La présente invention concerne une composition qui permet d'inhiber la métastase cancéreuse, ou de prévenir, de soulager ou de traiter le cancer, et qui comporte un milieu conditionné de cellules souches mésenchymateuses dérivées des amygdales. Son profil de protéines étant différent de celui des cellules souches mésenchymateuses dérivées d'autres tissus ou de milieux conditionnés de celles-ci, la composition de la présente invention présente une activité inhibitrice de la TEM qui lui permet d'empêcher la métastase cancéreuse, telle que la motilité et la pénétration des cellules cancéreuses, à un stade précoce, et d'induire l'apoptose des cellules cancéreuses. Ainsi, la composition présente d'excellents effets d'inhibition de la métastase cancéreuse, ainsi que de prévention, de soulagement et de traitement du cancer.본 발명은 편도 유래 중간엽 줄기세포의 조정배지를 포함하는 암 전이 억제, 암의 예방, 개선 또는 치료용 조성물에 관한 것이다. 본 발명의 조성물은 타 유래 중간엽 줄기세포 또는 이의 조정배지들과 상이한 단백질 프로파일을 가지고 이를 통해 EMT 억제작용으로 인한 암세포 이동 및 침투 등 암 전이를 초기 단계부터 억제하고 암세포 사멸을 유도하여, 암의 전이 억제와 암의 예방, 개선 및 치료에 우수한 효과를 가진다.
