PROBLEM TO BE SOLVED: To stably expose a vaccine antigen to a mucosal surface by adhering a high-concentration drug solution to the oral mucosa for a certain period of time in an oral mucosal adhesion type preparation, and completely dissolve the vaccine antigen within a predetermined time. To provide a vaccine preparation that adheres to the oral mucosa. SOLUTION: This is an oral mucosal adhesion type vaccine preparation having a drug layer containing a vaccine antigen and a drug cover layer, wherein the thickness of the drug cover layer is 15 μm or more and the temperature is 37 ° C. disintegration of the drug layer (a) and disintegration of the drug cover layer (B) has a relationship of (a)>； (B), a test piece of the drug cover layer area 20 cm 2 thickness 50 [mu] m, An oral mucosal adhesion type vaccine preparation which is immersed in 500 mL of distilled water at 37 ° C. and has a residual rate (C) of 50% or more and 90% or less 7 minutes after the start of immersion. [Selection diagram] None【課題】口腔内粘膜付着型の製剤で、口腔内粘膜に高濃度の薬物溶液を一定時間付着させることにより、粘膜面にワクチン抗原を安定的に暴露させ、所定時間内で完全に溶解させることのできる口腔内粘膜付着型ワクチン製剤を提供すること。【解決手段】ワクチン抗原を含む薬物層と、薬物カバー層とを有する口腔内粘膜付着型ワクチン製剤であって、上記薬物カバー層の厚みが、１５μｍ以上であって、３７℃の蒸留水に対する、上記薬物層の崩壊性（Ａ）及び上記薬物カバー層の崩壊性（Ｂ）が、（Ａ）＞（Ｂ）の関係を有し、面積２０ｃｍ２厚み５０μｍの上記薬物カバー層の試験片を、３７℃の蒸留水５００ｍＬに浸漬させ、浸漬開始から７分後の残存率（Ｃ）が、５０％以上９０％以下である口腔内粘膜付着型ワクチン製剤。【選択図】なし
