Cartridge (10) for storing and dispensing a flowable composition, which comprises(a) a hollow elongated body (11) having a proximal end (110) and a distal end (111)； said elongated body (11) forming a storage chamber (112) having a first opening (113) at the proximal end (110) and a second opening (114) at the distal end (111)；(b) a piston (12) slidably inserted into the first opening (113) of the elongated body (11) for sealingly closing the storage chamber (112)；(c) a discharge nipple (13) having an external thread (131), which is provided at the second opening (114), whereby the external thread has a handedness defining a first direction of rotation in which an internal thread (311) engaging the external thread (131) of the discharge nipple (13) moves away from the elongated body (11)； wherein the elongated body (11) is provided with a sleeve (115) at the proximal end (110), said sleeve (115) having a rack of one or more asymmetrical teeth (116) provided on the circumference of the sleeve (115), with each tooth (116) having a steep slope (117) facing the first direction and a moderate slope (118) facing a second direction opposite to the first direction.
