PROCEDES ET COMPOSITIONS DE MODULATIONS DE L'EXPRESSION DE LA FRATAXINE

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专利权人:

WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人:

ANSARI, ASEEM,ERWIN, GRAHAM,GRIESHOP, MATTHEW

申请号：

CA3019342

公开号：

CA3019342A1

申请日:

2017.03.29

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker； A- is a Brd4 binding moiety； and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.

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