A renal failure therapy system (10) includes a dialyzer (102)； a blood circuit (100) in fluid communication with the dialyzer (102)； a dialysis fluid circuit (30) in fluid communication with the dialyzer (102)； and an electrically floating fluid pathway (140) comprising at least a portion of the blood circuit (100) and at least a portion of the dialysis fluid circuit (30), wherein the only electrical path to ground is via used dialysis fluid traveling through machine (12) to earth ground (28), and wherein at least one electrical component (46, 90, 82, 66, 102, 116) in the at least a portion of the dialysis fluid circuit (30) of the electrically floating fluid pathway (140) is electrically bypassed.
