The present invention provides a vaccine, immunogenic polypeptide, and pharmaceutical compound, all including a serpinB13 protein or polypeptide or an immunogenic polypeptide that includes a serpinB13 protein or polypeptide coupled to an immunogenic agent. The present invention further includes use of these agents according to a method of inhibiting or delaying onset, or reducing the severity of type 1 diabetes, as well as a method of treating an individual for an immune condition selected from the group of psoriasis, hair loss, and ulcers including diabetic food ulceration.
