In an embodiment, a computer-implemented method of selecting locations in a field for treatment sampling is disclosed. The method comprises receiving, by a processor, input data including a number T of treatments applied to a field, a number L of treatment locations for each treatment, a list of treatment polygons within the field, and a map for the field indicating one or more values of a set of design parameters corresponding to environment factors for each of a plurality of locations in the field. The method also comprises computing, by the processor, an environment class index for each of a group of locations in the list of treatment polygons based on the map; distributing the list of treatment polygons to the T treatments based on the computed indices; and selecting, for each of the T of treatments, L treatment locations from the group of locations in the treatment polygons distributed to the treatment. In addition, the method comprises causing display of information regarding the selected treatment locations.