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Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
专利权人:
Kirk Patrick Seward
发明人:
Kirk Patrick Seward,Lynn Mateel Barr,Judith Carol Wilber,Robert Cafferata
申请号:
US12790541
公开号:
US08708995B2
申请日:
2010.05.28
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Methods and kits for delivering pharmaceutical agents to the adventitia and other regions outside the external elastic lamina (EEL) surrounding a blood vessel utilize a catheter having a needle. The needle is positioned in up to 5 mm beyond the EEL and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally and radially along the blood vessel. Confirmation that a delivery aperture of the needle lies beyond the EEL may be required before delivering the pharmaceutical agent.
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