S1PR2 antagonists and uses therefor

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专利权人:

Dalhousie University

发明人:

McMaster, Christopher,Simms, Gordon

申请号：

AU2016273436

公开号：

AU2016273436A1

申请日:

2016.06.01

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) through the administration of a therapeutically effective amount of a sphingosine-1-phosphate receptor type 2 (S1PR2) antagonist. Also provided herein are compounds which contain bioisosteric replacements of the urea group of JTE- 013 and analogs thereof, and their use in treating retinopathies and diseases characterized by insufficient angiogenesis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/