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DÉRIVÉS DE 1,7-NAPHTYRIDINE
专利权人:
F. HOFFMANN-LA ROCHE AG;HOFFMANN-LA ROCHE INC.
发明人:
CECCARELLI, Simona M.,JAGASIA, Ravi,JAKOB-ROETNE, Roland,PETERS, Jens-Uwe,WICHMANN, Juergen
申请号:
EPEP2014/066123
公开号:
WO2015/014768A1
申请日:
2014.07.28
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
The present invention relates to compounds of general formula (I) wherein R1 is phenyl or pyridinyl, which are optionally substituted by one, two or three substituents, selected from halogen, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen, cyano or S(O)2-lower alkyl, or is morpholinyl, dihydropyranyl or piperidinyl, wherein piperidinyl is optionally substituted by halogen, or is C(O)O-lower alkyl; R2 is hydrogen; R3 is hydrogen, lower alkyl substituted by halogen, –(CH2)n-S(O)2-lower alkyl, –(CH2)n- cycloalkyl or –(CH2)n-lower alkoxy; R4 is hydrogen or lower alkyl; n is 0, 1 or 2; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, cognitive impairment, chemotherapy-induced cognitive dysfunction ("chemobrain"), Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, and disturbances due to radiation therapy, chronic stress, optic neuropathy or macular degeneration, or abuse of neuro-active drugs, selected from alcohol, opiates, methamphetamine, phencyclidine and cocaine.La présente invention porte sur des composés représentés par la formule générale (I) dans laquelle R1 représente un groupe phényle ou un groupe pyridinyle, qui sont éventuellement substitués par un, deux ou trois substituants, choisis parmi les substituant atomes d'halogène, alkyle inférieur substitué par halogène, alcoxy inférieur, alcoxy inférieur substitué par halogène, cyano ou S(O)2-(alkyle inférieur) ou il re
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