#$%^&*AU2016203575B220171019.pdf#####ABSTRACT The present invention relates to an antibody which has a therapeutic effect on cancer, an autoimmune disease, or an inflammatory disease. That is, the present invention relates to an antibody which exhibits a cytotoxic activity against death domain-containing receptorexpressing cells through apoptosis. Object: An object of the invention is to provide a pharmaceutical having a therapeutic effect on cancer. Means for Resolution: A novel anti-DR5 antibody capable of inducing apoptosis in cells has more potent cytotoxic activity than currently available anti-DR5 antibodies.
