596971 Disclosed is the use of an inhibitor of miR-146a or miR-146b in the manufacture of a medicament for treating or preventing myocardial infarction, cardiac remodeling, or heart failure in a subject in need thereof, wherein the inhibitor is an antisense oligonucleotide or an antagomir, and wherein said medicament is formulated for administration to said subject to improve one or more symptoms of myocardial infarction, cardiac remodeling, or heart failure.