EULJI UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION;을지대학교 산학협력단;건국대학교 글로컬산학협력단;KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION
发明人:
PARK, SANG WOONG,박상웅,BAE, YOUNG MIN,배영민,PARK, SANG WOONGKR,BAE, YOUNG MINKR
申请号:
KR1020160144174
公开号:
KR1020180047640A
申请日:
2016.11.01
申请国别(地区):
KR
年份:
2018
代理人:
摘要:
The present invention relates to a pharmaceutical composition for treating and preventing hypertension, which comprises a carveollin-1 specific inhibitor or a carveollin-1 phosphorylation inhibitor as an active ingredient. The carveollin-1 specific inhibitor is antisense oligonucleotide, siRNA, shRNA or miRNA, bisphosphonate, or GGTI-286 specific for the carveollin-1 gene. The carveollin-1 phosphorylation inhibitor is imatinib, butein, mesylate, or PP2(4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d] pyrimidine).본 발명은 고혈압 치료 및 예방용 약학적 조성물에 관한 것으로서, 카베올린-1 특이적 저해제 또는 카베올린-1 인산화 억제제를 유효성분으로 함유하는 고혈압 치료 및 예방용 약학적 조성물을 제공한다.