The disclosed Wheelchair Contamination Shield is a fender for a wheelchair that covers a large portion of the tire, protects the user's fingers from contact with tire. Further, the Wheelchair Contamination Shield prevents fingers from being caught in gap between hand rim and wheel, where contact with the rotating standoffs can be harmful.The mounting system of the Wheelchair Contamination Shield optionally includes removable foam blocks and arcuate mounting slots. The combination of these elements simplifies the process of mounting the device on the wheelchair.