Paul SLOBBE,Alex Johannes POOT,Augustinus Antonius Maria Silvester VAN DONGEN,Heiko NIESSEN,Albert Dirk WINDHORST
申请号：
US14765042
公开号：
US20150368230A1
申请日:
2014.01.28
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Novel radiotracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging are described. Specifically, the invention relates to 18F-labeled afatinib suitable as a PET or SPECT tracer for imaging epidermal growth factor receptor (EGFR, erbB1) and human epidermal growth factor receptor 2 (Her2, erbB2), to a precursor compound for use in its synthesis, to methods for the preparation 18F-labeled afatinib, as well as to the use thereof in in vivo diagnosis, tumor imaging or patient stratification on the basis of mutational status of EGFR (erbB1) and Her2 (erbB2).
