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STABLE POWDER FORMULATION CONTAINING AN ANTICHOLINGERIC AGENT
专利权人:
Claudius WEILER;Michael TRUNK;Werner PIEROTH
发明人:
Michael TRUNK,Claudius WEILER,Werner PIEROTH
申请号:
US13706885
公开号:
US20130164344A1
申请日:
2012.12.06
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention relates to a spray-dried powder formulation comprising particles that contain the following components i) to iii): i) anticholinergic agents, in particular at least one compound of formula 1, in which X− represents a negatively charged anion, ii) at least one embedding material selected from the group consisting of mono- or disaccharides, oligosaccharides, polymers, sugar alcohols and cholesterol, iii) an organic, physiologically acceptable, sterically demanding acid, selected from the group consisting of ascorbic acid, a monovalent, divalent or trivalent carboxylic acid, with the exception of amino carboxylic acids, preferably fumaric acid, oxalic acid, or diacetic acid, and a fruit acid or culinary acid, preferably citric acid, tartaric acid, malic acid, lactic acid, acetic acid, α-hydroxycaprylic acid or gluconic acid. The invention also relates to a method for producing said formulation.
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