RESPIRATORY DISEASE-RELATED GENE SPECIFIC siRNA, DOUBLE-HELICAL OLIGO RNA STRUCTURE CONTAINING SUCH siRNA, AND COMPOSITION CONTAINING THE SAME FOR PREVENTING OR TREATING RESPIRATORY DISEASES
CHAE JEIWOOK,チェ ジェウク,PARK HAN OH,パク ハンオ,YOON PYOUNG OH,ユン ピョンオ,HAN BO RAM,ハン ボラム,KIM MI NA,キム ミナ
申请号：
JP2017134539
公开号：
JP2017225447A
申请日:
2017.07.10
申请国别(地区):
JP
年份:
2017
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide a gene specific siRNA related with respiratory diseases, a highly efficient double-helical oligo RNA structure containing the same, and a composition containing the same for preventing or treating respiratory diseases.SOLUTION: There is provided a double-helical oligo RNA structure represented by the structural formula 1 defined by A-X-R-Y-B, where A is a hydrophilic material； B is a hydrophobic material； X and Y are each independently a simple covalent bond or a linker-mediated covalent bond； and R is CTGF-specific siRNA.SELECTED DRAWING: Figure 1【課題】呼吸器疾患関連遺伝子特異的ｓｉＲＮＡおよびこれを含む高効率二重らせんオリゴＲＮＡ構造体及びこれを含む呼吸器疾患予防又は治療用組成物の提供。【解決手段】構造式１で表される二重らせんオリゴＲＮＡ構造体。Ａ－Ｘ－Ｒ－Ｙ－Ｂ（構造式１）（Ａは親水性物質；Ｂは疎水性物質；Ｘ及びＹは夫々独立して単純共有結合又はリンカー媒介された共有結合；ＲはＣＴＧＦ特異的ｓｉＲＮＡ）【選択図】図１
