Michienzi Joseph D.,Shreve Joshua A.,Hill Jason F.,Tarafder Abhijit,Fogwill Michael O.,Fadgen Keith
申请号：
US201815948653
公开号：
US2018292362(A1)
申请日:
2018.04.09
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
Methods for transferring a carbon dioxide based separation procedure from a reference chromatographic system to a target chromatographic system involve alternative techniques for determining system pressure drops not attributable to the column. One technique involves leveraging experimental chromatography to develop a correction factor that is a function of at least one correction coefficient and at least one ratio of the differential analyte retention time to the retention time in the reference system. Another technique involves leveraging other experimental measurements of tubing pressure drops under various condition to develop a lookup table that can be used to identify likely tubing pressure drops in the target system. A third technique leverages knowledge of the separation procedure and the target system and the likely nature of the relevant flow to calculate tubing pressure drops in the target system.
