Novel epoprostenol formulation and method for producing the same

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专利权人:

アクテリオン ワン エスエー

发明人:

パレプ、 ナグレシュ アール

申请号：

JP2008553381

公开号：

JP5415771B2

申请日:

2007.02.02

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

This invention relates to a stable epoprostenol composition that can be combined with commercially available IV fluids and can be administered in its reconstituted and/or diluted form under ambient conditions of about 15-30° C. for greater than 24 hours. The composition preferably contains (a) epoprostenol or a salt thereof； (b) a alkalinization agent； and (c) a base, such that when reconstituted or in solution, the solution has a pH>；11. Methods for making the lyophilized composition are also disclosed.

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