KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
LEE, You Mie,이유미
申请号：
KRKR2012/006909
公开号：
WO2013/032230A2
申请日:
2012.08.29
申请国别(地区):
WO
年份:
2013
代理人:
摘要：
The present invention relates to an angiogenic composition, and more particularly, to a pharmaceutical angiogenic composition including a microRNA-382 activator. The inventors of the present invention have confirmed that microRNA-382, the expression of which is elevated in stomach cancer cells in a low oxygen environment, affects the promotion of angiogenesis. Therefore, provided in the present invention is the pharmaceutical angiogenic composition which includes the microRNA-382 activator, which is angiogenic and thus promotes cell proliferation, and can be valuably used in treating injuries, ischemic myocardial infarctions, or foot ischemia.Linvention concerne une composition angiogène et plus particulièrement une composition pharmaceutique angiogène comprenant un activateur de microARN-382. Les inventeurs de la présente invention ont confirmé que le microARN-382 dont lexpression est élevée dans les cellules du cancer de lestomac dans des environnements pauvres en oxygène, modifie la promotion de langiogenèse. Ainsi, la composition pharmaceutique angiogène qui comprend lactivateur de microARN-382 est divulguée dans la présente invention, composition qui est angiogène et promeut ainsi la prolifération cellulaire et peut être utilisée de manière très avantageuse dans le traitement de blessures, de linfarctus du myocarde ischémique ou du pied ischémique.본 발명은 혈관신생촉진용 조성물에 관한 것으로, 보다 구체적으로는 microRNA-382의 활성화제를 포함하는 혈관신생촉진용 약학적 조성물에 관한 것이다. 본 발명자들은 저산소 환경의 위암세포에서 발현이 증가되는 microRNA-382가 혈관신생의 촉진에 영향을 미치는 것을 확인하였다. 따라서, 본 발명은 혈관신생을 촉진함으로써 세포의 증식을 촉진하여 상처 치유, 허혈성 심근경색, 또는 족부허혈의 치료에 유용하게 이용될 수 있는 microRNA-382 활성화제를 포함하는 약학적 조성물을 제공한다.
