PROCEDE DE FABRICATION D'UNE COMPOSITION PHARMACEUTIQUE SOUS FORME DE COMPRIMES A LIBERATION PROLONGEE CONTENANT DE LA PIRFENIDONE, UTILISATION POUR FAIRE REGRESSER L'INSUFFISANCERENALE CHRONIQUE, LA CONTRACTURE CAPSULAIRE MAMMAIRE ET LA FIBROSE HEPATIQUE CHEZ L'HOMME
ARMENDARIZ BORUNDA, JUAN,MAGANA CASTRO, JOSE AUGUSTIN ROGELIO,CERVANTES GUADARRAMA, JORGE
申请号：
CA2842654
公开号：
CA2842654A1
申请日:
2012.07.13
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to a method for manufacturing a pharmaceutical composition in the form of extended-release tablets that include from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), such that the drug containing same is bioavailable during an extended period of 12 hours from the administration thereof. This optimizes the anti-fibrotic and anti-inflammatory action of the Pirfenidone. Additionally, the present invention offers advantages and better therapeutic effectiveness over other pharmaceutical forms of Pirfenidone for oral administration and the therapeutic use thereof in the regression of chronic secondary renal insufficiency to primary glomerulosclerosis； it shows greater activity in the decrease and/or regression of the toxic effects on the breast capsular contracture observed after surgical implantation of breast implants in humans and exercises a significant anti-TNF-a and anti-TGF-ß? action in the treatment of hepatic fibrosis.
