The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.本発明は、アルキレンジアミンとヒアルロン酸の架橋ヒドロゲルを含む組織補強用充填組成物に関するものである。本発明の充填組成物は、生体内に長時間とどまることができるという有益な効果に加え、生体適合性や膨潤性など、組織補強に求められる有効な物性を示す。