Общество с ограниченной ответственностью "НоваМедика" (RU)
发明人:
РАСКОНИ Кристофер П. (US),ТОНКЕНС Росс М. (US)
申请号：
RU2012136951/15
公开号：
RU2012136951A
申请日:
2012.08.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method for introducing anticoagulant system subject in need thereof, wherein the system includes anticoagulant aptamer which binds Factor IX / IXa, and the antidote, aptamer that binds, comprising: a. measuring weight of the subject in kg b. administering to the subject an aptamer dose effective to achieve inhibition of coagulation in a subject, wherein the aptamer comprises the sequence SEQ ID No: 1, and wherein the aptamer dose is from 0.1 mg / kg to 2.0 mg / kg or 5 mg / kg to 10 mg / kg Isa. administering a dose of antidote aptamer to a subject, wherein the safener comprises the sequence SEQ ID No: 2 and the dose of antidote based only on the ratio w / w with a dose of aptamer, and wherein the ratio wt / wt dosages of the aptamer with a dose of antidote is from about 0.1: 1 to about 20: 1 and wherein the subject runs the peripheral revascularization procedures sosudov.2. A method according to claim 1, wherein the aptamer dose is from about 0.1 mg / kg to about 1.5 mg / kg.3. A method according to claim 1, wherein the aptamer dose is about 1.0 mg / kg.4. A method according to claim 1, wherein the aptamer dose is from about 0.6 mg / kg to about 0.8 mg / kg.5. A method according to claim 1, wherein the aptamer dose is from 0.1 to 2 mg / kg.6. A method according to claim 1, wherein the aptamer dose is from 5 to 10 mg / kg.7. A method according to claim 1, wherein the aptamer is administered by intravenous bolus vvedeniya.8. A method according to claim 1, wherein the aptamer is administered by subcutaneous inektsii.9. A method according to claim 1, wherein the aptamer and antidote is administered in a ratio weight / weight of from 0.25: 1 to 15: 1.10. A method according to claim 1, wherein the aptamer and antidote is administered in a ratio weight / weight of 0.5: 1 to 12: 1.11. A method according to claim 1, wherein the aptamer and antidote is administered in a ratio weight / weight of from 1: 9 to 1: 1.12. FPIC1. Способ введения противосвертывающей системы суб
