recombinant alpha galactosidase a and / or biologically active recombinant alpha galactosidase fragment, composition, recombinant polynucleotide sequence, expression vector, host cell, methods for producing a variant alpha galactosidase ae for treating and / or preventing symptoms of fabry, pharmaceutical composition, and, use of compositions.
GJALT W. HUISMAN,MATHEW G. MILLER,NICHOLAS J. AGARD,XIYUN ZHANG
申请号：
BR112017013300
公开号：
BR112017013300A2
申请日:
2015.12.02
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. Engineered human alpha-galactosidase polypeptides have been enhanced to provide improved stability under both acidic (ph <；4.5) and basic (ph>； 7) conditions. The invention also relates to the use of compositions comprising engineered human alpha-galactosidase polypeptides for therapeutic purposes.a presente invenção provê polipeptídeos de alfa-galactosidase humana engenheirados e composições dos mesmos. os polipeptídeos de alfa-galactosidase humana engenheirados foram aprimorados para prover estabilidade melhorada em condições tanto ácidas (ph <；4,5) quanto básicas (ph >；7). a invenção também se refere ao uso das composições compreendendo os polipeptídeos de alfa-galactosidase humana engenheirados para propósitos terapêuticos.
