The present invention provides methods to prepare cinnarizine (Cnz)–ß-cyclodextrin (ß-Cd) complexes by the kneading, co- precipitation and co-evaporation methods with (ternary system) or without (binary system) the addition of two different hydrophilic polymers (HPMC and PVP) in their two different grades (HPMC E5-LV or K4M and PVP K-25 or K-30). The present invention also enables to determine the polymers influence on enhancing the Cnz solubility and the in vitro Cnz liberation behaviour or drug permeation characteristics via arti?cial membrane from the prepared Cnz–ß-Cd binary and ternary complexes in 0.1 N HCl (pH 1.2).
