Technische Universität Wien;Veterinärmedizinische Universität Wien
发明人:
JENNER, Florien,ROSSER, Julie,ERTL, Peter
申请号：
AU2018319335
公开号：
AU2018319335A1
申请日:
2018.08.22
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
Disclosed is a three-dimensional tissue culture, comprising chondrocytes in a biocompatible artificial matrix, having at least the following layers: a first layer located at or close to a surface of the matrix, wherein chondrocytes have a non- spherical shape and are arranged essentially in parallel to the surface along their longest dimension； and a second layer at least partially covered by the first layer wherein the mean sphericity of the chondrocytes of the second layer is higher than the mean sphericity of the chondrocytes of the first layer； and preferably a third layer at least partially covered by the second layer, wherein chondrocytes are arranged into columns extending into the matrix, wherein each column has at least two chondrocytes. Such a tissue culture may for instance be used as artificial cartilage in surgery. Also disclosed is a method to produce such a three-dimensional culture.
