HOLMDAHL, RIKARD,KIHLBERG, JAN,DZHAMBAZOV, BALIK,VESTBERG, MIKAEL
申请号：
CA2629881
公开号：
CA2629881C
申请日:
2006.11.15
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention relates a compound comprising (a) a peptide and (b) a carrier,wherein said peptide having at least the motif X-X-X-X-X-X-X, wherein at leastone amino acid residue X is glycosylated, said peptide being linked to thepeptide binding protein and said carrier comprises at least a MHC bindingmotif being linked to said peptide as well as pharmaceutical compositionscomprising said compound and the use of said compound or pharmaceuticalcomposition for the treatment of a disease, such as an inflammatory jointdisease. The subject matter of the application is exemplified with peptidesderived from type II collagen such as peptides having at least the sequenceAGFKGEA, or IAGFKGEQPKG, or the peptide AAAKAAA. Preferably a hydroxylysine inthe peptides are glycosylated.
