The invention relates to highly biocompatible or biophilic un-cross-linked orcross-linked polymers comprising one or more side-chain active acrylic aminoacids of formula (I). The invention further concerns various highlybiocompatible, cross-linked co-polymers comprising one or more monomers offormula (I), and one or more other polymerizable monomers. Uses of suchpolymers and co-polymers for the production of contact lenses, intraocularlenses, implants, wound healing slabs, additives for food and cosmetics,conductive plastics, spinnable fibers, and the like are disclosed.