HERVÉ BOUCHARD,RAVI V. J. CHARI,ALAIN COMMERÇON,YONGHONG DENG,LAURENCE GAUZY
申请号:
BRPI0814267
公开号:
BRPI0814267A2
申请日:
2008.07.18
申请国别(地区):
BR
年份:
2015
代理人:
摘要:
The present invention is related to new tomaymycin derivatives having a linking chain between two units of pyrrolo[2,1c][1,4]benzodiazepines, substituted by a non-cleavable linker and their conjugated to cell binding agents, their process of preparation and their therapeutic uses.