PHARMACOLOGICAL MODULATION OF POSITIVE AMPA RECEPTOR MODULATOR EFFECTS ON NEUROTROPHIN EXPRESSION

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专利权人:

Julie C. Lauterborn;Gary Lynch;Christine M. Gall

发明人:

Julie C. Lauterborn,Christine M. Gall,Gary Lynch

申请号：

US13654366

公开号：

US20130123248A1

申请日:

2012.10.17

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Antagonists of group 1 metabotropic glutamate receptors (mGluR) potentiate the effect of positive AMPA receptor modulators on neurotrophin expression, such as brain-derived neurotrophic factor (BDNF). The findings described herein suggest a combinatorial approach for drug therapies, using both positive AMPA receptor modulators and mGluR antagonists, to enhance brain neurotrophism.

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中国工程科技知识中心

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